M Babyak 1, J A Blumenthal, S Herman, P Khatri, M Doraiswamy, K Moore, W E Craighead, T T Baldewicz, K R Krishnan
- PMID: 11020092
- DOI: 10.1097/00006842-200009000-00006
Objective: The purpose of this study was to assess the status of 156 adult volunteers with major depressive disorder (MDD) 6 months after completion of a study in which they were randomly assigned to a 4-month course of aerobic exercise, sertraline therapy, or a combination of exercise and sertraline.
Methods: The presence and severity of depression were assessed by clinical interview using the Diagnostic Interview Schedule and the Hamilton Rating Scale for Depression (HRSD) and by self-report using the Beck Depression Inventory. Assessments were performed at baseline, after 4 months of treatment, and 6 months after treatment was concluded (ie, after 10 months).
Results: After 4 months patients in all three groups exhibited significant improvement; the proportion of remitted participants (ie, those who no longer met diagnostic criteria for MDD and had an HRSD score <8) was comparable across the three treatment conditions. After 10 months, however, remitted subjects in the exercise group had significantly lower relapse rates (p = .01) than subjects in the medication group. Exercising on one’s own during the follow-up period was associated with a reduced probability of depression diagnosis at the end of that period (odds ratio = 0.49, p = .0009).
Conclusions: Among individuals with MDD, exercise therapy is feasible and is associated with significant therapeutic benefit, especially if exercise is continued over time.
- Novel Augmentation Strategies in Major Depression.Martiny K.Dan Med J. 2017 Apr;64(4):B5338.PMID: 28385173 Review.
- Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.Hoffman BM, Babyak MA, Craighead WE, Sherwood A, Doraiswamy PM, Coons MJ, Blumenthal JA.Psychosom Med. 2011 Feb-Mar;73(2):127-33. doi: 10.1097/PSY.0b013e31820433a5. Epub 2010 Dec 10.PMID: 21148807 Free PMC article. Clinical Trial.
- Effects of exercise training on older patients with major depression.Blumenthal JA, Babyak MA, Moore KA, Craighead WE, Herman S, Khatri P, Waugh R, Napolitano MA, Forman LM, Appelbaum M, Doraiswamy PM, Krishnan KR.Arch Intern Med. 1999 Oct 25;159(19):2349-56. doi: 10.1001/archinte.159.19.2349.PMID: 10547175 Clinical Trial.
- Exercise and pharmacotherapy in the treatment of major depressive disorder.Blumenthal JA, Babyak MA, Doraiswamy PM, Watkins L, Hoffman BM, Barbour KA, Herman S, Craighead WE, Brosse AL, Waugh R, Hinderliter A, Sherwood A.Psychosom Med. 2007 Sep-Oct;69(7):587-96. doi: 10.1097/PSY.0b013e318148c19a. Epub 2007 Sep 10.PMID: 17846259 Free PMC article. Clinical Trial.
- Adjunctive low-dose aripiprazole with standard-dose sertraline in treating fresh major depressive disorder: a randomized, double-blind, controlled study.Lin CH, Lin SH, Jang FL.J Clin Psychopharmacol. 2011 Oct;31(5):563-8. doi: 10.1097/JCP.0b013e31822bb0db.PMID: 21869699 Clinical Trial.
- Depression and Atherosclerotic Cardiovascular Disease (ASCVD) Risk Estimator in Women.Iordani MM, Polikandrioti M, Kapadohos T, Maggita A, Kourea K, Koutelekos I, Dousis E, Zartaloudi A.Adv Exp Med Biol. 2023;1425:131-139. doi: 10.1007/978-3-031-31986-0_12.PMID: 37581787
- The effectiveness of the National Veterans Summer Sports Clinic for veterans with probable posttraumatic stress disorder.Walter KH, Otis NP, Hose MK, Ober KM, Glassman LH.Front Psychol. 2023 Jul 10;14:1207633. doi: 10.3389/fpsyg.2023.1207633. eCollection 2023.PMID: 37492451 Free PMC article.
- OUTdoor Swimming as a nature-based Intervention for DEpression (OUTSIDE): study protocol for a feasibility randomised control trial comparing an outdoor swimming intervention to usual care for adults experiencing mild to moderate symptoms of depression.Massey H, Denton H, Burlingham A, Violato M, Bibby-Jones AM, Cunningham R, Ciccognani S, Robertson S, Strauss C.Pilot Feasibility Stud. 2023 Jul 13;9(1):122. doi: 10.1186/s40814-023-01358-3.PMID: 37443045 Free PMC article.
- A Two-Year Longitudinal, Cross-Sectional Evaluation of Resident Physician Burnout: An Exploration of the Effects of Stress, Satisfaction, Exercise and EMR.Dziadkowiec O, Durbin JS, Novak ML, Patt-Rappaport Z, Guldner G.HCA Healthc J Med. 2021 Apr 28;2(2):123-132. doi: 10.36518/2689-0216.1254. eCollection 2021.PMID: 37425643 Free PMC article.
- Sex-specific effects of voluntary wheel running on behavior and the gut microbiota-immune-brain axis in mice.Williams ZAP, Szyszkowicz JK, Osborne N, Allehyany B, Nadon C, Udechukwu MC, Santos A, Audet MC.Brain Behav Immun Health. 2023 Apr 24;30:100628. doi: 10.1016/j.bbih.2023.100628. eCollection 2023 Jul.PMID: 37396336 Free PMC article.
- Antidepressive Agents / therapeutic use*
- Combined Modality Therapy
- Depressive Disorder, Major / diagnosis
- Depressive Disorder, Major / therapy*
- Follow-Up Studies
- Middle Aged
- Psychiatric Status Rating Scales
- Sertraline / therapeutic use*
- Severity of Illness Index
Grants and funding
- HL43028/HL/NHLBI NIH HHS/United States
- HL49572/HL/NHLBI NIH HHS/United States
- MH 49679/MH/NIMH NIH HHS/United States