M Babyak 1, J A Blumenthal, S Herman, P Khatri, M Doraiswamy, K Moore, W E Craighead, T T Baldewicz, K R Krishnan
Affiliations expand
- PMID: 11020092
- DOI: 10.1097/00006842-200009000-00006
Abstract
Objective: The purpose of this study was to assess the status of 156 adult volunteers with major depressive disorder (MDD) 6 months after completion of a study in which they were randomly assigned to a 4-month course of aerobic exercise, sertraline therapy, or a combination of exercise and sertraline.
Methods: The presence and severity of depression were assessed by clinical interview using the Diagnostic Interview Schedule and the Hamilton Rating Scale for Depression (HRSD) and by self-report using the Beck Depression Inventory. Assessments were performed at baseline, after 4 months of treatment, and 6 months after treatment was concluded (ie, after 10 months).
Results: After 4 months patients in all three groups exhibited significant improvement; the proportion of remitted participants (ie, those who no longer met diagnostic criteria for MDD and had an HRSD score <8) was comparable across the three treatment conditions. After 10 months, however, remitted subjects in the exercise group had significantly lower relapse rates (p = .01) than subjects in the medication group. Exercising on one’s own during the follow-up period was associated with a reduced probability of depression diagnosis at the end of that period (odds ratio = 0.49, p = .0009).
Conclusions: Among individuals with MDD, exercise therapy is feasible and is associated with significant therapeutic benefit, especially if exercise is continued over time.
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Publication types
MeSH terms
- Antidepressive Agents / therapeutic use*
- Combined Modality Therapy
- Depressive Disorder, Major / diagnosis
- Depressive Disorder, Major / therapy*
- Exercise*
- Female
- Follow-Up Studies
- Humans
- Middle Aged
- Psychiatric Status Rating Scales
- Sertraline / therapeutic use*
- Severity of Illness Index
Substances
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- HL43028/HL/NHLBI NIH HHS/United States
- HL49572/HL/NHLBI NIH HHS/United States
- MH 49679/MH/NIMH NIH HHS/United States
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